Possible Regulation of Platelets by Native and Modified Low Density Lipoprotein-Cholesterol Particles
نویسندگان
چکیده
منابع مشابه
Possible Regulation of Platelets by Native and Modified Low Density Lipoprotein-Cholesterol Particles
An excess number of low density lipoprotein-cholesterol (LDL-C) particles is an independent risk for a cardiovascular event in the future. LDL particles diffused into the developing atherosclerotic plaques bind to proteoglycans in the intima, become oxidized and phagocytosed to macrophages. This causes the generation of foam cells, which aggravate the generation of fatty streaks and induce plat...
متن کاملcholesterol/high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, non–high-density lipoprotein cholesterol, or low-density lipoprotein particle concentration and guideline categories of low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol
International clinical practice guidelines on dyslipidemia emphasize the importance of matching the use and intensity of statin therapy with the absolute risk of atherosclerotic cardiovascular disease (CVD). Indeed, independent of the baseline level of dyslipidemia, patients who have entered the intervention arms of randomized clinical trials of statin therapy with similar absolute risks of CVD...
متن کاملBeyond Low-Density Lipoprotein Cholesterol
Recent clinical trials in patients with coronary artery disease (CAD) provide evidence that low-density lipoprotein cholesterol (LDL-C) levels should be lowered even further to prevent recurrent CAD. However, despite more aggressive interventions for lowering LDL-C levels, the majority of CAD events go undeterred, perhaps related to the fact that intervention was not started earlier in life or ...
متن کاملNon-oxidative modification of native low-density lipoprotein by oxidized low-density lipoprotein.
The oxidative modification of low-density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis, although little is known as yet about the precise mechanism of oxidation in vivo. The studies presented here demonstrate that, in the absence of cells or transition metals, oxidized LDL can modify native LDL through co-incubation in vitro such as to increase its net negative c...
متن کاملClinical significance of high-density lipoprotein cholesterol in patients with low low-density lipoprotein cholesterol.
OBJECTIVES We sought to evaluate the significance of high-density lipoprotein cholesterol (HDL-C) in the context of low low-density lipoprotein cholesterol (LDL-C). BACKGROUND Earlier studies support an inverse correlation between circulating HDL-C and coronary risk in patients with normal or elevated LDL-C. METHODS This study involved 4,188 patients attending the Palo Alto Veterans Adminis...
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ژورنال
عنوان ژورنال: Korean Circulation Journal
سال: 2012
ISSN: 1738-5520,1738-5555
DOI: 10.4070/kcj.2012.42.8.519